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- W2363876697 abstract "Objective To study the expression of serine protease 2(PRSS2) in cell lines and tissues of pancreatic carcinoma,and provide a new target for early diagnosis and treatment of pancreatic carcinoma.Methods It was shown by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF-MS) that one differential protein spot was most similar to PRSS2.Pancreatic carcinoma tissues and normal pancreatic tissues,20 samples for each,and 4 pancreatic carcinoma cell lines were collected to detect the mRNA expression of PRSS2 by RT-PCR and qRT-PCR.The relationship was analyzed between the relative quantities of PRSS2 mRNA expression in pancreatic carcinoma tissues and tumor biological parameters.Results PRSS2 expressed in all pancreatic carcinoma tissues,normal pancreatic tissues and pancreatic carcinoma cell lines.The relative quantities of pancreatic carcinoma and normal pancreas were 33.76(6.47,107.98) and 3.74(0.96,28.83),respectively.The relative quantities of PRSS2 mRNA expression in pancreatic carcinoma were notably higher than those in normal pancreatic tissues(P0.05).The PRSS2 mRNA expressions in pancreatic carcinoma tissues were not relative to tumor biological parameters such as tumor differentiation,tumor size,lymph node metastasis,CA19-9 and CEA.Conclusions PRSS2,which is highly expressed in pancreatic carcinoma juice,can be a potential tumor marker for diagnosis of pancreatic carcinoma.It is feasible to screen the differential proteins from pancreatic carcinoma juice as the markers for the early diagnosis of pancreatic carcinoma." @default.
- W2363876697 created "2016-06-24" @default.
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- W2363876697 date "2009-01-01" @default.
- W2363876697 modified "2023-09-28" @default.
- W2363876697 title "Expression of serine protease 2 in cell lines and tissues of pancreatic carcinoma" @default.
- W2363876697 hasPublicationYear "2009" @default.
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