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- W2363882021 abstract "Objective To evaluate the clinical application significance of serum procalcitonin(PCT) quantitation determination in the diagnosis of systemic and local bacterial infections. Methods The Clinical and Laboratory Standards Institute(CLSI) EP15-A2 document was employed to verify the precision and accuracy of PCT determination by Roche Cobas E601 chemiluminescence analyzer(Cobas E601) and ensure instrument conditions being complied with the requirement of experiment. A total of 697 patients with systemic and local bacterial infections were enrolled. The results of serum PCT determination,blood culture,sputum culture,middle-urine culture and cerebrospinal culture were used to compare the change trends of serum PCT for systemic and local bacterial infections and for different-part infections. The difference of PCT in Gram-positive cocci and Gram-negative bacilli infections was analyzed. Results Cobas E601 had good repeatability,and the total coefficient of variation(CV) was 3. 59%. The fixed calibration bias was 5. 0% and met the clinical determination requirements. For serum PCT,there was significance for systemic and local bacterial infections with having increasing serum PCT level(P 0. 05). For local bacterial infection,there was no statistical significance for respiratory system,urinary system and nervous system infections(P 0. 05). For systemic bacterial infection,there was higher serum PCT level for patients with Gram-negative bacilli infection than with Grampositive cocci infection(P 0. 05). For local bacterial infection,there was no statistical significance for patients with Gram-negative bacilli infection and Gram-positive cocci infection(P 0. 05). Conclusions In patients with systemic and local bacterial infections,serum PCT level has high expression,and serum PCT level can not identify local bacterial infection Gram-negative bacilli and Gram-positive cocci infections." @default.
- W2363882021 created "2016-06-24" @default.
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- W2363882021 date "2015-01-01" @default.
- W2363882021 modified "2023-09-24" @default.
- W2363882021 title "The clinical application of PCT in the diagnosis of systemic and local bacterial infections" @default.
- W2363882021 hasPublicationYear "2015" @default.
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