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- W2363886648 abstract "Objective:To study the synthesis and in vitro anti-cancer activity of new curcumin derivatives.Method:Three new curcumin derivatives were synthesized using anti-tumor ingredients of Shiquandabu Wan as starting materials.Our idea was enlightened by the ‘combination principle ' in drug discovery.The curcumin derivatives anti-tumor activities were evaluated on the HT-29,Bel-7402,HepG2 and Hela human cancer cell lines and their toxicities were evaluated on MDCK(madin-darby canine kidney cell lines).Result:Compound 4 and CU-T displayed more antiproliferative activities on these cancer cells than their starting materials;IC50values were similar to DDP's,while curcumin derivatives showed much lower toxicity on MDCK cell than DDP.Conclusion:It is feasible to discover high-effect and low-toxicity lead compounds from classic formulas via combination principle." @default.
- W2363886648 created "2016-06-24" @default.
- W2363886648 creator A5084589205 @default.
- W2363886648 date "2014-01-01" @default.
- W2363886648 modified "2023-09-23" @default.
- W2363886648 title "Synthesis and Anti-tumor Evaluation of New Curcumin Derivants" @default.
- W2363886648 hasPublicationYear "2014" @default.
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