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- W2363933138 abstract "Objective:To identify a serum microRNA(miRNA)expression profile in stable angina pectoris(SAP)patients,which could serve as a novel diagnostic biomarker.Method:Serum samples were taken from 150 SAP patients and 50 controls.An initial screening of miRNA expression by microarray was performed using serum samples pooled from 20SAP patients and 10controls,respectively.Differential expression was validated using hydrolysis probe-based stem-loop quantitative reverse transcription polymerase chain reaction(qRT-PCR)in individual samples.Result:The microarray results demonstrated that 26serum miRNAs were markedly different in the SAP patients compared to the controls.The qRT-PCR analysis further identified a profile of five serum miRNAs(miR-215,miR-502,miR-208,miR-487aand miR-29b)as biomarkers for SAP detection.The areas under the receiver operating characteristic(ROC)curve of the five serum miRNAs were 0.992,0.807,0.836,0.991and 0.893respectively.Some of five serum miRNA were associated with the severity of coronary stenosis.Conclusion: Expression levels of some serum miRNAs could be novel biomarkers for early detection of SAP in humans and the serum miRNA may play a key role in the process of atherosclerosis." @default.
- W2363933138 created "2016-06-24" @default.
- W2363933138 creator A5014699286 @default.
- W2363933138 date "2014-01-01" @default.
- W2363933138 modified "2023-09-23" @default.
- W2363933138 title "Serum microRNA expression profiling in patients with stable angina pectoris" @default.
- W2363933138 hasPublicationYear "2014" @default.
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