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- W2363948247 abstract "Aim To investigate the neuroprotective effects of Resveratrol pretreatment after cerebral ischemia in mice.Methods SPF male Kunming mice(n=72) were randomly divided into 4 groups:sham-operated group,ischemia group,ischemia+vehicle group and ischemia+Resveratrol group(Each group of 18 mice).Immunohistological and RT-PCR assessments were performed to evaluate the effects.The pathological changes of brain tissue and infarct volume were observed by 2,3,5-triphenytetrazolium chloride(TTC) staining,and the score of neurological function was evaluated by Zea-Longa test.Results Compared with the ischemia and ischemia+vehicle groups,the expression of BDNF and NT-3 obviously increased(P0.01) in Resveratrol group,but the infarct volume and the neurological function scores were decreased significantly in Resveratrol group(P0.01).Conclusion Resveratrol can improve the neurological function through decreasing the infarct volume and increasing the expression of BDNF and NT-3 after cerebral ischemia in mice." @default.
- W2363948247 created "2016-06-24" @default.
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- W2363948247 date "2012-01-01" @default.
- W2363948247 modified "2023-09-23" @default.
- W2363948247 title "Effects of Resveratrol on brain derived neurotrophic factor and neurotrophin-3 of cerebral ischemia of mice" @default.
- W2363948247 hasPublicationYear "2012" @default.
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