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- W2363960746 abstract "Objective To study the impedance detected by the whole blood electrical impedance aggregometry in evaluating the effect of antiplatelet therapy.Methods The imprecision of the two different assays(the whole blood electrical impedance aggregometry and the plasma light transmission aggregometry) was compared.Thirty healthy volunteers and 60 patients with coronary artery disease under antiplatelet treatment were enrolled in the present study,whose anti-aggregated blood were collected for the measurement of electrical impedance in the presence of ADP,arachidonic acid and collagen,respectively.Finally,we analysed the agreement between the results of the two different assays which were used to measured the antiplatelet effect of aspirin and clopidgrel.Results The imprecision analysis showed the CV,(the whole blood electrical impedance aggregometry was 4.8%,superior to the plasma light transmission aggregometry (CV = 7.7%).In healthy control group,the mean impedances were(9.6±3.4)Ω、(10.4±2.8)Ω and (13.5±2.2)Ω in the presence of ADP,arachidonic acid and collagen as in the patients taking aspirin 100 mg/day,the 95% patients' results were 0 Ω.Furthermore,the mean impedance of patients taking aspirin 100 mg/day and/or clopidogrel 75 mg/day was significantly lower than that of healthy volunteers(ADP as agonist,t = 2.391,P0.05;araehidonic acid as agonist,t =4.057,P0.01;collagen as agonist t = 2.047, P 0.05).The value of patients taking 100 mg/day aspirin and 75 mg/day clopidgrel at the same time was significantly lower than that of patients taking 100 mg/day aspirin alone(t = 3.646,P 0.01).We found a longer starting aggregation time in patients suspicious to have aspirin resistance than in healthy volunteers in the presence of arachidonic acid.There was good agreement between the results from the two different assays which were used to measured the antiplatelet effect of aspirin(Kappa value = 1)and clopidgrel(Kappa value = O.67).Conclusions It is important that we measure the effect of platelet aggregation inhibitors by the whole blood electrical impedance aggregometry with multi-agonist to evaluate the antiplatelet treatment effect." @default.
- W2363960746 created "2016-06-24" @default.
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- W2363960746 date "2007-01-01" @default.
- W2363960746 modified "2023-09-23" @default.
- W2363960746 title "Quantifying the effect of antiplatelet therapy by whole blood platelet aggregometry" @default.
- W2363960746 hasPublicationYear "2007" @default.
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