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- W2363973239 abstract "OBJECTIVE To establish a HPLC method for determining the serum clonazepam concentrations in epileptic children.METHODS With Nova Pak C 18 column,the mobile phase was consisted of 35% acetonitrile and 65% 0.01 mol·L -1 sodium acetate.Phenytoin was used as the internal standard.It was extracted by tertbutylanisole and drying at room temperature.The residue was reconstitued by the mobile phase and then analyzed at UV 254 nm.RESULTS The good linearity was obtained over the range of 5.0～100.0 μg·L -1 with correlation coefficient r =0.9990.At three concentrations,the average recoveries were 99.80%,99.34% and 99.62%,respectively. RSD of within day were 1.14%,3.76% and 3.30%,respectively. RSD of between day were 1.58%,1.71% and 4.73%,respctively.The minimal detectable concentration was 2.0 μg·L -1 .The steady state serum concentrations were 13.04～39.14 μg·L -1 in 11 epileptic children after oral administration of clonazepam.CONCLUSION This method can provide the basis for clinical effective and safe treatment of clonazepam." @default.
- W2363973239 created "2016-06-24" @default.
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- W2363973239 date "2001-01-01" @default.
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- W2363973239 title "Studies on high performance liquid chromatographic determination of clonazepam in serum" @default.
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