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- W2363973610 abstract "Objective To investigate the effect of Na~+,K~+-ATPase in depression and the relationship between Na~+,K~+-ATPase and monoamine neurotransmitters in rats.Methods The depression models of SD rats were established by chronic stimulation randomly for 21 days.The mRNA expression of myocardium Na~+,K~+-ATPase,the enzyme activity,norepinephrine(NA) and 5-hydroxyindoleacetic acid(5-HIAA,the metabolic product of serotonin)that participated in the regulation of affection,sleeping and memory,were detected.Results The transcriptional levels of Na~+,K~+-ATPase were decreased in depression models of rats.The activity of Na~+,K~+-ATPase was decreased in rat depression model.NA and 5-HIAA contents in hippocampus were significant decreased in depression rats.Conclusion The change of nerrohumor factors may be one of the primary causes for the change of myocardium Na~+,K~+-ATPase in depression.The enzyme may be of physiological and pathologic significance in pathogenesy of depression." @default.
- W2363973610 created "2016-06-24" @default.
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- W2363973610 date "2009-01-01" @default.
- W2363973610 modified "2023-09-24" @default.
- W2363973610 title "Myocardium Na~+,K~+-ATPase activity and its mRNA expression in depression in rats" @default.
- W2363973610 hasPublicationYear "2009" @default.
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