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- W2363988483 abstract "The interactions between asiaticoside(AC) and calf thymus DNA(ctDNA) in physiological buffer(pH 7.4) were investigated by fluorescence,circular dichroism(CD) and FT-IR spectroscopy,coupled with ctDNA melting studies and viscosity measurements.The results showed that the fluorescence of AC could be quenched by ctDNA,and the potential mechanism of which could be static quenching.The binding of AC to ctDNA could increase the melting temperature and relative viscosity of DNA,which suggested the binding mode was an intercalation binding.The changes in CD and FT-IR spectra of ctDNA indicated the adenine and thymine base pairs could be the mainly binding sites,and the B conformation of ctDNA might be stabilized by AC.The calculated thermodynamic parameters suggested that hydrogen bonds and van der Waals forces were the main force in the binding of AC to ctDNA." @default.
- W2363988483 created "2016-06-24" @default.
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- W2363988483 date "2013-01-01" @default.
- W2363988483 modified "2023-09-24" @default.
- W2363988483 title "Detection of interaction between asiaticoside and DNA by multispectroscopic techniques" @default.
- W2363988483 hasPublicationYear "2013" @default.
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