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- W2363998844 abstract "OBJECTIVE:To investigate the distribution of let-7 target gene KRAS-binding domain rs712 polymorphism in patients with glioma and healthy controls and its correlation with clinical features of glioma.METHODS:The KRAS rs712 polymorphism was genotyped in 153 patients with glioma and 204 healthy controls using polymerase chain reaction-restriction fragment length polymorphism method.RESULTS:The frequencies of GG,GT,and TT genotypes of rs712 were 67.2%,29.9% and 2.9% in controls,54.2%,36.6% and 9.2% in patients with glioma,respectively.The TT and GT/TT genotypes were associated with increased risks of glioma compared with the GG genotype(TT vs GG:χ~2=7.93,OR=3.85,95%CI:1.43-10.41,P=0.005;GT/TT vs GG:χ~2=6.16,OR=1.73,95%CI:1.12-2.66,P=0.013,respectively).The frequencies of G and T alleles of rs712 were 82.1% and 17.9% in controls;and 72.5% and 27.5% in patients with glioma,respectively.Similarly,the T allele was correlated to a significantly increased risk of glioma compared with the G allele(χ~2 =9.31,OR=1.74,95%CI:1.22-2.48,P=0.002).The frequencies of GT/TT genotypes and T allele in the Ⅲ-Ⅳ grade glioma patients were significantly higher than those in patients with stage Ⅰ-Ⅱ(GT/TT vs GG:χ~2=4.40,OR=1.99,95%CI:1.04-3.81,P=0.036;T vs G:χ~2=5.51,OR=1.83,95%CI:1.10-3.04,P=0.019,respectively).CONCLUSION:KRAS rs712 allele polymorphism may be one of the susceptibility factors for glioma." @default.
- W2363998844 created "2016-06-24" @default.
- W2363998844 creator A5047687303 @default.
- W2363998844 date "2013-01-01" @default.
- W2363998844 modified "2023-09-27" @default.
- W2363998844 title "Association between the single nucleotide polymorphism of let-7 targetgene KRAS-binding site rs712 and risk of glioma" @default.
- W2363998844 hasPublicationYear "2013" @default.
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