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- W2364001027 abstract "To investigate the protective effect of Iguratimod( T614) against lipopolysaccharide( LPS) induced systemic inflammation and multiple organ damage in mice,a systemic inflammation and multiple organ damage mouse model by intraperitoneal injection LPS 5 mg / kg were established. The results showed the death rate,clinical symptoms,organ index and histopathological findings of positive drug control group( prednisone) 5 mg / kg and T614 30 mg / kg and 90 mg / kg dose groups were improved obviously than the model group. The blood biochemical parameters( ALT,AST,ALP,BUN,CREA and UA) were lower obviously than the model group( P 0. 01),the hematological parameters( WBC,RBC,PLT and RET) were in the same level comparing with the blank control group. The results show T614 diminishes LPS-induced systemic inflammation and multiple organ damage in mice." @default.
- W2364001027 created "2016-06-24" @default.
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- W2364001027 date "2014-01-01" @default.
- W2364001027 modified "2023-09-23" @default.
- W2364001027 title "Iguratimod Diminishes LPS-induced Systemic Inflammation in Mice" @default.
- W2364001027 hasPublicationYear "2014" @default.
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