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- W2364001593 abstract "Objective Changes of neurotrophin-3(NT-3) expression in rat motocortex following complete spinal cord transection were studied in order to provide the experimental evidences for the mechanisms of regeneration and repair after spinal cord injury and for neurotrophins to treat spinal cord injury. Methods Male Sprague-Dawley rats weighing 240-260 g were divided into three groups at random: ①Spinal cord transection group which was randomly subdivided into four subgroups according to the survival time at the day 1,3,7 and 14 d after operation(n=6 for each time point),in which the spinal cord of rat was transected completely at thoracic level 10-11;②Sham operation group(laminectomy only,n=6);③Normal control group(n=6).The expression of NT-3 in motocortex was examined by immunohistochemistry and image analysis.Results NT-3 immunoreactive cells were found in motocortex layer Ⅴ in both control and spinal cord t ransection groups.After operation,the expression of NT-3 increased gradually and reached the peak at the day 3 after operation in motocortex.Conclusion The results suggest that the expression of NT-3 increases in motocortex after spinal cord injury and that the increase of endogenous NT-3 may be beneficial for the survival and regeneration of the injured corticospinal neurons." @default.
- W2364001593 created "2016-06-24" @default.
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- W2364001593 date "2006-01-01" @default.
- W2364001593 modified "2023-09-27" @default.
- W2364001593 title "Changes of NT-3 expression in rat motocortex following complete spinal cord transection" @default.
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