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- W2364008900 abstract "Objective:To explore the protective effect and the mechanism of cordyceps extract on renal tissue in rats with ischemia reperfusion injury.Methodology:The kidneys of seventy-two male Sprague-Dawley rats were randomly divided into 3 groups:saline group,kidney preservation solution(HCA group),and artificial cordyceps liquid composite group(CS-HCA group).We observed the degree of tubulo-interstitial lesions,apoptosis index(AI)of the renal tubular epithelial cell and superoxide dismutase(SOD)activity and concentration of malondialdehyde aldehyde(MDA)in kidney at 6h,12h and 24h after perfusion respectively.Results:(1)The degree of renal lesion in CS-HCA group was lighter than those in the other two groups at 6h after perfusion.The degree of renal lesion in both HCA group and CS-HCA group was lighter than saline group at 12h after perfusion.It was no differences for degree of renal lesion among 3 groups at 24h after perfusion.(2)Comparison with HCA group and saline group,CS-HCA group had lower AI(P0.05)and MDA concentration(P0.05),and higher SOD activity(P0.05)at 6 and 12h after perfusion.But no difference among three groups in AI and SOD activity,and MDA concentration(P0.05).(3)It was negative correlated between AI and SOD activity(r=-0.724),positive ratio between AI and MDA concentration(r=0.681).Conclusion:Cordyceps artificial compound could protect the kidney against renal ischemia reperfusion injury in rats,which of mechanism may be associated with the effects of free radical and lipid peroxidation." @default.
- W2364008900 created "2016-06-24" @default.
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- W2364008900 date "2010-01-01" @default.
- W2364008900 modified "2023-09-22" @default.
- W2364008900 title "Protective effect of cordyceps artificial compound on renal tissue in rats with ischemia-reperfusion injury" @default.
- W2364008900 hasPublicationYear "2010" @default.
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