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- W2364009750 abstract "Objective The effect of dandelion extract(DE) on expression of P53 and Ki67 in gastric cancer MKN45 cell were studied as a way to evaluate the antitumor effects of Mongolian dandelion herb. Methods 20 mice were used to prepare four groups of the mouse blood serum(including a normal control group and three groups of different concentrations of DE).After the serums were added in the gastric cancer MKN45 cell culture media respectively,the expression of P53 protein and Ki67 protein were examined respectively by streptavidin-peroxidase conjugated method(SP). Results The expression of p53 was found 100%(5/5),60%(3/5),80%(4/5) and 60%(3/5) respectively in the four groups.The positive rate of p53 in DE groups(all the groups together) was lower than that in control group;the expression of Ki67 was found 87.0%,96.0%,97.5% and 92.0% in the four groups.The expression of Ki67 in each group of the three DE groups was higher than that in control group. Conclusion There is a weak experimental evident to show that TE decrease the expression of P53 in gastric cancer MKN45 cell while increased the expression of Ki67." @default.
- W2364009750 created "2016-06-24" @default.
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- W2364009750 date "2012-01-01" @default.
- W2364009750 modified "2023-09-23" @default.
- W2364009750 title "EFFECT OF DANDELION EXTRACT ON EXPRESSION OF P53 AND KI67 IN GASTRIC CANCER MKN45 CELL LINES" @default.
- W2364009750 hasPublicationYear "2012" @default.
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