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- W2364011452 abstract "Objective To establish the rabbit model of mixed reflux esophagitis by mixed perfusion of hydrochloric acid and bile.Methods The rabbit model of mixed reflux esophagitis was established by mixed perfusion of hydrochloric acid and bile.The model groups were divided into four-day,seven-day,ten-day group.The normal group was perfused with the solution of Sodium Chloride.The esophagus pathological changes in the different groups were observed by macroscopic observation,the optical microscope,and the electronic microscope.And the pathological grade of the different groups were compared.Results Significant pathological changes were observed in the lower esophageal bot-tom.The general form by macroscopic observation: The mucosa in the lower part of the esophagus in the normal group was smooth,and there was no blood vessel hyperplasia under the mucosa.The esophageal mucosa in the model group existed diverse levels of rough and hyperemia,and blood vessel hyperplasia under the mucosa,sporadic or extensive erosion and diverse levels of ulcer were observed too.The score of macroscopic observation among three model groups were significantly different(P0.01).under the optical microscope,there was no pathological changes in the mucosa and the muscle layers in the normal group.In the model group,there were diverse levels of pyknosis and defluxion of squamous epithelium,the infiltration of eosinophile and neutrophil,dilation and hyperemia in the submucosa,and diverse levels of ulcer and tissue necrosis,as well as diverse levels of inflammatory cell infiltration of the mus-cle layer was observed.The pathological scores in the three model groups were significantly different(P0.05).Under the electronic microscope,there were diverse levels swelling of the chondriome and dilation of the peripheral sarcoplasmic reticulum.Conclusion It is successful to establish the rabbit model of the acid and bile mixed reflux esophagitis by mixed perfusion." @default.
- W2364011452 created "2016-06-24" @default.
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- W2364011452 date "2009-01-01" @default.
- W2364011452 modified "2023-09-23" @default.
- W2364011452 title "The Study on the Rabbit Model of Mixed Reflux Esophagitis" @default.
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