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- W2364012303 abstract "Objective:To explore the possibility of five modified nucleosides:Pseu,m1A,m1I,m1G and m2G being molecular markers in diagnosis of lung cancer.Methods:The concentrations of Pseu,m1A,m1I,m1G and m2G in urine from 55 cases of lung cancer patients(including 18 cases of squamous cell carcinoma,23 cases of adenocarcinomas and 14 cases of small cell lung cancer)and 30 cases of healthy adults were detected by high performance liquid chromatography(HPLC)online system.The concentration of creatinine in urine from all of those objects was detected by high performance liquid chromatography(HPLC).The concentration of nucleosides was indicated by the ratio of nucleosides to creatinine.The correlation of the concentration of urinary modified nucleosides to the occurrence and histology types of lung cancer was analyzed.Results:The concentrations of Pseu,m1A,m1I,m1G and m2G from lung cancer patients were significantly higher than those from normal adults(P=0.000).The concentration of m1I in the small cell lung cancer group was significantly higher than that in the adenocarcinoma group(P=0.045).The sensitivity of combined detection of Pseu,m1A and m1I was the same as that of combined detection of 4 or 5 kinds nucleosides,and which was significantly higher than single detections of m1A in lung cancer,respectively(P=0.037).Conclusion:The urinary modified nucleosides:Pseu,m1A,m1I,m1G and m2G may become molecular markers in diagnosis of lung cancer and be helpful for the histological classification of lung cancer." @default.
- W2364012303 created "2016-06-24" @default.
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- W2364012303 date "2010-01-01" @default.
- W2364012303 modified "2023-09-23" @default.
- W2364012303 title "The feasibility study of five modified nucleosides in urine used as molecular markers in high-risk groups screening of lung cancer" @default.
- W2364012303 hasPublicationYear "2010" @default.
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