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- W2364013128 abstract "AIM To investigate the correlation between the occurrence and development of glioma and the expression of suppressor gene and control of cell cycle. METHODS Theexpressions of p21 WAF1/CIP gene and p53 gene were observed with immunohistochemical method in 63 human glioma tissues and 10 normal brain tissues. RESULTS ① All of the normal brain tissues registered p21 WAF1/CIP1 positive expressions; the positive rates of p21 WAF1/CIP1 expression and the degrees of differentiation in glioma tissues were positively correlated. ② Only one of the ten normal brain tissues had a mutant p53 gene weak positive expression. The positive rates of mutant p53 gene expression and the degrees of differentiation in glioma tissues were negatively correlated. ③ In most of mutant p53 protein negative tissue, p21 WAF1/CIP protein was present and vice versa. CONCLUSION The loss or mutation of suppressor gene p21 WAF1/CIP may be related to the occurrence and development of glioma. The mutant p53 can cause reduction or disappearance of p21 WAF1/CIP and the expression of p21 WAF1/CIP is mainly regulated by p53. The inhibition of tumor growth by wild p53 gene may be achieved by p21 WAF1/CIP gene expression." @default.
- W2364013128 created "2016-06-24" @default.
- W2364013128 creator A5073800512 @default.
- W2364013128 date "2000-01-01" @default.
- W2364013128 modified "2023-09-24" @default.
- W2364013128 title "Relationship between p21~(WAF1/CIP1) gene expression and p53 gene in glioma" @default.
- W2364013128 hasPublicationYear "2000" @default.
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