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- W2364013560 abstract "Objective:To assess the effects of endotracheal versus intramuscular injection of naloxone in serious neonatal asphyxia resuscitation.Methods:A random clinical trial was undertaken in infants with serious asphyxia,of 40 infants with 1-minute Apgar score 1 to 3,20 received an endotracheal injection of naloxone(0.2 mg·kg-1)(endotracheal group,ET group)and 20 received an intramuscular injection(0.2 mg·kg-1)(intramuscular group,IM group),10 minutes later followed a half dose of naloxone in two group which were performed same treatment after tracheal intubation.The 1-minute,3-minute and 5-minute Apgar score,time of spontaneous respiration,respiration frequency and heart rate were observed.Results:The 3-minute and 5-minute Apgar score were significantly higher in ET group than IM group(P0.05).After naloxone injection,HR in two group was obviously increased as it compared with baseline,and HR in ET group was significantly higher than in IM group.For ET and IM group,the time of spontaneous respiration was 92.4 s and 148.6 s(P0.01),the respiration frequency was 48.5 bpm and 39.4 bpm(P0.01).Conclusions:During the serious neonatal asphyxia resuscitation without an effective venous channel and/or tracheal intubated,the endotracheal delivery of naloxone is more powerful than intramuscular injection,the time of asphyxia and spontaneous respiration were significantly shortened." @default.
- W2364013560 created "2016-06-24" @default.
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- W2364013560 date "2008-01-01" @default.
- W2364013560 modified "2023-09-23" @default.
- W2364013560 title "Clinical Trial of Endotracheal Versus Intramuscular Injection of Naloxone in Serious Neonatal Asphyxia Resuscitation" @default.
- W2364013560 hasPublicationYear "2008" @default.
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