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- W2364016629 abstract "Objective To observe the clinical efficacy and anticoagulant effects and safety of low-molecular-weight heparin (LMWH) on treatment of refractory nephrotic syndrome(NS).Methods 33 patients of primary NS complicated with hypercoagulability were randomly divided into two groups: the control and the treatment groups. The control group was treated with prednisolone(1mg/kg/d) plus oral cyclophosphamide (50mg bid) and methylprednisolone 0 5～1g(20mg/kg/time) in glucose 250ml(5%) intravenously by drip . While the treated group was administered, on the basis of the therapeutic scheme of the control group, with subcutaneous injection of LMWH (5000IU bid) for 4 weeks, the clinical symptom was observed in both groups before and after the treatment ,the 24h urine protein quantitative determination,renal function,anti thrombin III (AT-III) activity,fibrinogen(FIB),D-dimer(DD),plasma factor Xa( Fxa),plasma factor IIa(FIIa) were also tested, the side effects in two groups were observed at the same time. Results The 24h urine protein quantitative determination,blood urea nitrogen(BUN) and serum Cr were significantly decreased(P0 05)in both groups ,whereas the serum albumin(ALB) and the endogenous creatinine clearance rate(Ccr)were obviously increased(P0 05) after four weeks treatment in the two groups . But the decrement in the 24h proteinuria and the improvement of the ALB in the treated group were higher,as compared with those in the control group(P0 05), and the healing rate and excellent effective rate in the treatment group was higher than those in the control group(P0 05), and the inefficiency rate in the treatment group was lower than that in the control group(P0 05).A significant improvement in AT-III activity (P0 05) and decrement in FIB,DD,FXa(P0 05) and no significant changes in FIIa were observed in the treatment group,not any intravenous thrombosis was found in these patients. In the control group, no significant change in these markers was found, and deep venous thrombosis was found in 4 patients.Conclusions On the basis of the prednisolone plus cyclophosphamide treatment,the LMWH can relieve the hypercoagulability ,improve renal function and decrease the thrombotic complications of patients with refractory nephrotic syndrome ." @default.
- W2364016629 created "2016-06-24" @default.
- W2364016629 creator A5075638826 @default.
- W2364016629 date "2003-01-01" @default.
- W2364016629 modified "2023-09-28" @default.
- W2364016629 title "Clincial Observation on the Efficacy of Low Molecular Weight Heparin on Treatment of Refractory Nephrotic Syndrome" @default.
- W2364016629 hasPublicationYear "2003" @default.
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