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- W2364016750 abstract "Objective:To approach the effects of eliminating pathogenic factor from Moyuan therapy,heat-clearing and toxin-relieving therapy,and removing heat to cool blood therapy on nuclear factor-kappa B p50 in acute lung injury(ALI).Methods:The model of ALI in mouse was established by intravenous injection of lipopolysaccharide(10 mg/kg).Mice were randomized into normal control group,model control group,heat-clearing and toxin-relieving group,removing heat to cool blood group,and eliminating pathogenic factor from Moyuan group.Levels of nuclear factor-kappa B p50,lung-body index,and histopathologic changes in lung tissue were observed.Results:There were massive bleeding,necrosis,and inflammatory cell infiltration in lung tissues of model control group;in heat-clearing and detoxicating group,there were mild bleeding,bronchiolar epithelial hyperplasia in local lung tissues without destruction of the structure of lung tissue;there was a small hemorrhagic focus in lung tissue of removing heat to cool blood group,and mild inflammation in lung interstitium of eliminating pathogenic factor from Moyuan group.Compared with normal control group,the lung-body index in heart-clearing and toxin-nelieving group was higher,P0.05.Compared with model control group,the positive ratios of nuclear factor-kappa B p50 in three treatment groups were significantly lower,P0.05-0.01.Conclusion:Heat-clearing and toxin-relieving therapy,removing heat to cool blood therapy and eliminating pathogenic factor from Moyuan therapy can all protect lung tissue in ALI,which may be associated with the suppression of the expression of nuclear factor-kappa B p50." @default.
- W2364016750 created "2016-06-24" @default.
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- W2364016750 date "2007-01-01" @default.
- W2364016750 modified "2023-09-26" @default.
- W2364016750 title "Different Chinese Medical Therapies for the Expression of Nuclear Factor-kappa p50 in Acute Lung Injury" @default.
- W2364016750 hasPublicationYear "2007" @default.
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