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- W2364041693 abstract "Objective To study the inhibitory effect of methylmercury chloride(MMC) on human SHG44 glioma cells in vitro.Methods The human SHG44 galimo cells were cultivated in vitro and divided into control group and MMC-treated group.MMT assay was performed to evaluate the proliferation inhibitory effect and cytotoxicity effect of MMC with different concentrations on cultured human SHG44 glioma cells,and flow cytometry was used to assess the effects of MMC treatment on cell apoptosis in human SGH44 glioma cells.Results 1.25,2.50,5.00 and 10.00 μmol·L-1MMC could inhibit the proliferation of cultured human SGH44 glioma cells in vitro,the viabilities of MMC treated human SGH44 glioma cells were significantly lower than those in control group(P0.05),the inhibitory effect was in a dose-dependent manner.The cell viabilities of human SGH44 glioma cells treated with 2.50,5.00 and 10.00 μmol·L-1MMC for 4,8,16 and 32 h were significantly lower than those in control group(P0.05),the cytotoxicity effect was in a dose and time independent manner.When SGH44 glioma cells were treated with 0.075,0.15,0.3 and 1.2 μmol·L-1MMC for 12 h,the apoptosis/necrosis rates were significantly higher than those in control group(P0.01);decreased(P0.01).Conclusion MMC has cytotoxicity effect on cultured human SGH44 glioma cells in vitro,and can inhibit proliferation and induce apoptosis." @default.
- W2364041693 created "2016-06-24" @default.
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- W2364041693 date "2010-01-01" @default.
- W2364041693 modified "2023-09-28" @default.
- W2364041693 title "Inhibitory effect of methylmercury chloride on human SHG44 glioma cells in vitro" @default.
- W2364041693 hasPublicationYear "2010" @default.
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