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- W2364052015 abstract "Objective To purify gp96 protein and observe its therapeutic efficacy through the model of implanted liver cancer in mice and disscuss the mechanism of gp96.Methods After the tumor were successfully implanted in the liver,the 4 groups received different treatments.Tumor resection was performed in group Ⅰ without immunotherapy.The mice in group Ⅱ received gp96 after tumors were removed.Tumor resection was not performed in group Ⅲ,just vaccinated with gp96.The group Ⅳ served as control group.IL 10,IFN γ in serum and the alteration of proportions of CD 8 + IFNγ + and CD 8 + IL 10 + cells,CD 4 + IFNγ + and CD 4 + IL 10 + cells were tested on the 28th day.The 51 Cr release assay was used to examine the cytotoxicities of the splenocytes to H22 cells.Results In group Ⅱ,serum IFN γ was increased and IL 10 decreased as compared with other groups ( P 0.01); The proportions of CD 8 + IFNγ + and CD 4 + IFNγ + cells were increased,CD 8 + IL 10 + and CD 4 + IL 10 + cells were decreased obviously as compared with other groups ( P 0.01); Specific cytocytic rate of splenocytes was 39.3% when E∶T was 100∶1,significantly higher than that from the other groups.Conclusion gp96 can elicit specific cellular immune response and improve the host's antitumor immune response." @default.
- W2364052015 created "2016-06-24" @default.
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- W2364052015 date "2003-01-01" @default.
- W2364052015 modified "2023-09-25" @default.
- W2364052015 title "Immunotherapeutic effect of a novel tumor antigen-gp96 on liver cancer in mice" @default.
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