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- W2364062769 abstract "Objective To Evaluate the efficacy and tolerability of letrozole in neoadjuvant endocrine therapy of elderly postmenopausal breast cancer patients and its correlation with clinicopathologic factors.Methods 58 cases of postmenopausal hormone receptor-positive breast cancer treated with letrozole,compared with tamoxifen in neoadjuvant endocrine therapy.Results Letrozole was more effective than tamoxifen in clinical response rates(P0.05).Letrozole response rate was significantly higher in late clinical stage or ER and PR positive patients and had nothing to do with HER-2 expression.Tamoxifen was significantly less effective in HER2+ tumors.The expression of Ki-67 decreased remarkably after treatment of letrozol or tamoxifen.They were well-torerated in the neoadjuvant setting.Conclusion Neoadjuvant endocrine therapy with letrozole for postmenopausal hormone receptor-positive breast cancer is effective and safe,especially for frail elderly women concomitant with some serious diseases." @default.
- W2364062769 created "2016-06-24" @default.
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- W2364062769 date "2012-01-01" @default.
- W2364062769 modified "2023-09-23" @default.
- W2364062769 title "Clinical Observation of Letrozole in Neoadjuvant Endocrine Therapy for Elderly Breast Cancer" @default.
- W2364062769 hasPublicationYear "2012" @default.
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