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- W2364077668 abstract "Objective:To investigate phenotypic transition of smooth muscle cells(SMCs)in a porcine coronary restenosis model. Methods:A total of 12 experimental domestic pigs were randomly divided into two groups:control group(n=6)and restenosis group(n=6).Pigs in control group received sham-operation,and the other 6 pigs were implanted 1 stent in the left anterior descending coronary artery and circumflex coronary artery respectively.Histomorphology was observed by HE staining.Cell morphology and structure was examined by electron microscopy.The expression of connexin(Cx)43,Cx40,α-smooth muscle actin(α-SMA),S100 calcium binding protein A4(S100A4)in SMCs of coronary artery were examined by western blot. Results:Spindle-SMCs(S-SMCs)were predominant in control group,whereas rhomboid-SMCs(R-SMCs)were in higher proportion in restenosis group.Cx40 andα-SMA were highly expressed in control group(P0.01).In contrast,Cx43 and S100A4 were markedly upregulated in restenosis group(P0.01). Conclusion:The switch from S-SMC to R-SMC phenotype may be involved in restenosis after percutaneous coronary intervention." @default.
- W2364077668 created "2016-06-24" @default.
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- W2364077668 date "2014-01-01" @default.
- W2364077668 modified "2023-09-23" @default.
- W2364077668 title "Phenotypic change of smooth muscle cells in restenosis after percutaneous coronary intervention" @default.
- W2364077668 hasPublicationYear "2014" @default.
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