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- W2364077983 abstract "Resveratrol(3,4,5′-erihydroxystilbene,Res.) is a highly potential and selective antiretroviral nature product.The Res.has shown a strong synergistic anti-HIV activity in combination with nucleoside analogues in vitro.It is possible that during combination therapy,drug interaction may arise in vivo that would influence their antiviral activity.To investigate in vivo Res.synergistic antiretroviral activity in combination with nucleoside analogues,experiments involving combination of Res.,AZT and 3Tc,were performed in a murine model of immunodeficiency(MAIDS),an AIDS-like disease caused by the Friend-MuLV retroviral in susceptible BALB/c mice.Subsequently,the antiretroviral activity of AZT and/or 3Tc plus Res.in the MAIDS was evaluated and compared with AZT and 3Tc or Res.,administered as single drug.The results obtained showed that Res.did not show markedly antiviral activity.Weak potential antiretroviral was suggested only at a dose of 100 mg/kg body weight(20.78% splenomegaly reduction).Res.in combination with AZT and 3Tc is able to reduce WBC count(83.34%),splenomegaly(91.70%),and upgrade CD_4~+/CD_8~+ values.However,upon AZT plus 3Tc administration,similar result was obtained(WBC count and splenomegaly reduction).Furthermore,These results overlapped those obtained upon AZT plus 3Tc administration(87.5% splenomegaly and 82.25% WBC count reduction).Thus despite strong synergistic anti-HIV activity alone or in combination with nucleoside analogues in vitro,no synergy between Res.plus AZT or 3Tc was observed in Friend-MAIDS and administration of AZT and 3Tc does not improve the antiviral results obtained by Res.administration." @default.
- W2364077983 created "2016-06-24" @default.
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- W2364077983 date "2006-01-01" @default.
- W2364077983 modified "2023-09-27" @default.
- W2364077983 title "The Potential Synergistic Activity of Resveratrol Development in Combination Therapy of the Murine AIDS" @default.
- W2364077983 hasPublicationYear "2006" @default.
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