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- W2364088570 abstract "Objective To determine the expression changes of calcium concentration and Ire1 after spinal cord ischemia/reperfusion injury(SCII) in the rat,so as to investigate their role in endoplasic reticulum stress.Methods By using experimental SCII in the rat.The calcium concentration and Ire1 express level was detected by biochemistry method,immunohistochemistry,western blotting,RT-PCR and imagy-analysis after SCII in the rat.Results After progressive compression of spinal cord,the Ca2+ concentration in neurons was increased respectively in 3,7,14 d after operation.There was a significant difference between operation group and control group(P0.05).The expression of Ire1 mRNA and Ire1 was obviously increased in 1 d after operation.and rapidly elevated in 3,7,14 d after operation,and then the expression of Ire1 mRNA and Ire1 was decreased in 21,28 d after operation.There was a significant difference between the operation group and the control group(P0.05).Conclusion The increase of Ca2+ concentration in the neurons might be a factor trigering the endoplamic reticulum stress induced by progressive compression spinal cord.The increase of Ire1 expression suggest that the unfold protein accumulated in the ER,indicating the neurons were in the stage of ERS.In summary,the above mentioned results imply that Ca2+,Ire1 might participate in the signal transduction of apoptosis induced by endoplasmic reticulum stress in progressive compression spinal cord ischemic injury." @default.
- W2364088570 created "2016-06-24" @default.
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- W2364088570 date "2009-01-01" @default.
- W2364088570 modified "2023-09-23" @default.
- W2364088570 title "Changes of neuron calcium and Ire1 in progressive compression spinal cord injury" @default.
- W2364088570 hasPublicationYear "2009" @default.
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