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- W2364095028 abstract "To study the effects of dan shen pill(DSP) on myocyte apoptosis and the expression of apoptosis-associated genes in rat henrts with myocardial ischemia and reperfusion(MIR). MIR models were performed by a ligation or release of left coronary artery(LCA) in rats. Myocyte apoptosis and the protein expression of Fas and Bcl-2 genes were estimated by terminal deoxynucleotide transferase(TdT) mediated-dUTP nick end labeling (TUNEL) and S-P immunohistochemistry respectively. Results Compared with sham-operated group,the apoptotic index (AI) and the positive expresion index (PEI) of Fas and Bcl-2 proteins in myocytes increased significantly in MIR group[AI(%):19.82±8.6 vs 0.36±0.05; Fas PEI(%):17.44±6.08 vs 0.21±0.03; Bcl-2 PEI(%):6.79±1.84 vs 0.24±0.03; all P0.01]. Compared with MIR group,AI and PEI of Fas proein were lower and decreased gradually with the increase in Dan Shen pills doses in group with Dan Shen pills treatment(P0.05,P0.01). A large dose of Dan Shen pills could upregulate the protein expression of Bcl-2 gene (P0.05). Dan Shen pills can protect myocardium against ischemic and reperfused injury by inhibiting myocyte apoptosis,downregulate the protein expression of Fas gene and upregulate the protein expression of Bcl-2 gene." @default.
- W2364095028 created "2016-06-24" @default.
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- W2364095028 date "1999-01-01" @default.
- W2364095028 modified "2023-09-25" @default.
- W2364095028 title "THE EFFECTS OF DAN SHEN PILLS ON MYOCYTE APOPTOSIS AND THE EXPRESSION OF APOPTOSIS-ASSOCIATED GENES IN RAT HEARTS WITH MYOCARDIAL ISCHEMIA AND REPERFUSION" @default.
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