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- W2364097735 abstract "Objective To investigate the effect of serum B cell activating factor belonging to TNF family(BAFF)on the pathogenisis of systemic lupus erythematosus(SLE).Methods The serum BAFF levels of 45 SLE patients and normal controls were measured by ELISA,the C3 and C4 serum levels were detected quantitatively by turbidimentry.The SLE disease activity was assessed using the systemic lupus activity measure(SLAM) and organ damage using the systemic lupus international collaborating clinics/ACR(SLICC/ACR) damage index.The association of the serum BAFF level with serum C3 and C4 levels,SLAM,SLICC/ACR damage index were analyzed respectively.Results The serum BAFF level of SLE patients was significantly higher than that of normal controls.The serum BAFF level of anti-dsDNA antibody positive SLE patients was significantly higher than that of anti-dsDNA antibody negative patients,both P0.001.The serum BAFF level was negatively correlated with C3 level(r=-0.298,P=0.047),positively correlated with SLAM(r=0.450,P=0.002) and SLICC/ACR damage index(r=0.388,P=0.009).Conclusions BAFF is involved in the pathogenesis of SLE.The serum BAFF level may be an index for evaluation of SLE disease activity and prognosis;BAFF antagonists may improve the condition of SLE." @default.
- W2364097735 created "2016-06-24" @default.
- W2364097735 creator A5013357777 @default.
- W2364097735 date "2011-01-01" @default.
- W2364097735 modified "2023-09-23" @default.
- W2364097735 title "Detection and significance of serum B cell activating factor in patients with systemic lupus erythematosus" @default.
- W2364097735 hasPublicationYear "2011" @default.
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