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- W2364099058 abstract "Objective To observe the synergistic radiosensitization of paclitaxel(PA) and gemcitabine(GE), along with their mechanism on nasopharyngeal carcinoma(NPC) cell line HNE_ 2 . Methods Cytotoxicity was performed by exposing HNE_ 2 cells to GE or PA or GE plus PA, followed by irradiation. The Radiation Enhancement Ratio(RER)was evaluated by clonogenic assay. Cell cycle distribution and apoptosis were assessed by flow cytometry. The bcl-2 and bax protein expression were detected by Western Blot. Results The ERE of GE, PA and combined therapy was 1.06 , 1.13 , 1.34 ,respectively. The rate of S phase block and apoptosis related to GE was 96.03 % and 31.62 %, respectively, being 75.71 % G_ 2 /M phase block and 44.56 % apoptosis by PA. For cocktail therapy,the ratio of G_ 2 /M phase arrest induced by PA was decreased from 75.71 % to 65.98 %, while the ratio of S phase block was increased to 33.33 %,together with more apoptosis observed( 73.28 %). Western blot showed that both GE and PA increased the level of Bax expression and inhibited the level of bcl-2 expression. When PA and GE combined, they further increased Bax and inhibited bcl-2 protein expression. Conclusion PA and GE can enhance radiosensitization independently for HNE_ 2 cells. When combined,they showed synergistic effect. And it indicated that the radiosensitizing effects of both drugs could be related to apoptosis." @default.
- W2364099058 created "2016-06-24" @default.
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- W2364099058 date "2006-01-01" @default.
- W2364099058 modified "2023-09-26" @default.
- W2364099058 title "The Synergistic Radiosensitization of Paclitaxel and Gemcitabine on Nasopharyngeal Carcinoma Cell line HNE_2" @default.
- W2364099058 hasPublicationYear "2006" @default.
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