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- W2364101230 abstract "AIM: To investigate the effect of heat shock protein 90(HSP90) on proliferation of human breast cancer cells by a specific inhibitor for HSP90,geldanamycin(GA),and to analyze its molecular mechanisms.METHODS: Human breast cancer cell line MDA-MB-435s was used as a model.Proliferation of MDA-MB-435s cell was measured with MTT assay.Cell cycle was analyzed by flow cytometry.Alteration of phosphorylated Stat3 protein and mutant p53 protein in cells was detected by Western blotting.RESULTS: Geldanamycin inhibited the proliferation of MDA-MB-435s cells in time-and dose-depending manners.After treatment with GA,MDA-MB-435s cell cycle was arrested at G2/M phase.The levels of phosphorylated protein Stat3 and mutant p53 protein in MDA-MB-435s cells were reduced obviously by 55% and 48% respectively after 48 hour treatment with GA at the concentration of 400 nmol/L,compared to control cells.CONCLUSION: Inhibition of HSP90 function can prevent breast cancer cell proliferation significantly,which may be related to down-regulatin of the phosphorylated Stat3 protein and mutant p53 protein in the cells." @default.
- W2364101230 created "2016-06-24" @default.
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- W2364101230 date "2007-01-01" @default.
- W2364101230 modified "2023-09-23" @default.
- W2364101230 title "Effect of heat shock protein 90 on proliferation of human breast cancer cells and its molecular mechanisms" @default.
- W2364101230 hasPublicationYear "2007" @default.
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