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- W2364103048 abstract "Objective To investigate the effects of taurine on p38 mitogen-activated protein kinase (p38MAPK) signaling pathway and pro-inflammatory cytokines,tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in Kupffer cells (KCs) from severe acute pancreatitis (SAP) rats. Methods Sprague-Dawley rats were randomized into three groups: ① sham operation group (SO),② SAP group,③ SAP plus taurine group (SAP+Taur). The SAP model was created by retrogressive injection of 5% sodium taurocholate solution through the bili-pancreatic duct. Rats in SAP+taurine group were injected with taurine (3 mmol/L,0.1 ml/100 g) through the vena caudalis at 12 and 24 h before the establishment of SAP model. Rats from each group were sacrificed at 12 and 24 h after sham operation or SAP treatment. The levels of serum transaminase and amylase were detected. Then KCs in each group were isolated. The activities of p38 MAPK and NF-κB DNA in KCs were detected by Western blotting and electrophoretic mobility assay respectively. The levels of TNF-α and IL-1β in the supernatant were determined by ELISA. Results In SAP group,the levels of serum transaminase and amylase were significantly higher than those in SO group (P0.01),but in SAP+Taur group,they were significantly lower than those in SAP group (P0.05). The activities of p38 MAPK and NF-κB in KCs in SAP rats were significantly higher than those in sham operation rats (P0.01). SAP could also enhance the protein expressions of TNF-α and IL-1β in the supernatant (P0.01). These events were significantly inhibited by treatment with taurine. Conclusion The inhibited activation of p38MAPK and the down-regulated expression of NF-κB may contribute the inhibitory effect of taurine on the secretion of pro-inflammatory cytokines,TNF-α and IL-1β. Therefore,taurine may be of potential clinical application for the prevention and treatment of SAP." @default.
- W2364103048 created "2016-06-24" @default.
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- W2364103048 date "2009-01-01" @default.
- W2364103048 modified "2023-09-22" @default.
- W2364103048 title "Effects of taurine on p38 mitogen-activated protein kinase signaling pathway in Kupffer cells from severe acute pancreatitis rats" @default.
- W2364103048 hasPublicationYear "2009" @default.
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