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- W2364103304 abstract "Objective To study the effect of anti-angiogenesis drug,ES(Endostatin),on blood perfusion in tumor-induced angiogenesis.Method Based on numerical simulation of the tumor-induced angiogenesis,we assume blood as incompressible Newtonian fluid and calculate vascular flow rate and transvascular flow rate with extended Poiseuille's law and Starling's law.Interstitial flow follows Darcy's law and hydraulic permeability of the vascular wall is influenced by Endostatin.Then,we simulate the blood perfusion of tumor-induced angiogenesis under Endostatin with difference method.Result Under the effect of Endostatin,the number of blood vessel and the interstitial pressure in tumor tissue domain decreases,while the pressure gradient increases.Conclusion Besides decrease of tumor-induced angiogenesis,Endostatin changes the hydraulic permeability of the vascular wall,improves the hemodynamic environment of tumor tissue and is propitious to transportation of other drugs." @default.
- W2364103304 created "2016-06-24" @default.
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- W2364103304 date "2009-01-01" @default.
- W2364103304 modified "2023-09-23" @default.
- W2364103304 title "Numerical Simulation of Blood Perfusion in Tumor-induced Angiogenesis under Endostatin" @default.
- W2364103304 hasPublicationYear "2009" @default.
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