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- W2364103621 abstract "Objective To analyze the clinical significance of DNA stemline ploidy and its heterogeneity in hepatocellular carcinoma.Methods Paraffin embeded specimens of 45 heptocellular carcinomas were collected in this study.4 μm and 10 μm slices were prepared,respectively.DNA stemline ploidy and its parameters were determined by image cytometry in the tissue section.The optical density of nuclear DNA in the 4 μm slice was measured,whereas the volume of the intact nuclear in the 10 μm slices was measured.The total DNA of the intact nuclear volume was calculated by image cytometry,and lymphocytes in the same slice was taken as the control,the value of its DNA stemline ploidy was calculated.The relationship of DNA stemline ploidy heterogeneity and the tumor volume,histological classification,lymph metastasis,and α-fetoprotein level were statistically analyzed.Results There was a significant statistical relation between DNA stemline ploidy and its heterogeneity and the tumor volume,histological classification,lymph metastasis,and α-fetoprotein level.Conclusion Analysis on DNA stemline ploidy and its heterogeneity is valuable in pathological diagnosis,malignan grading,evaluation of therapeutic effect and prediction of prognosis of hepatocellular carcinoma." @default.
- W2364103621 created "2016-06-24" @default.
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- W2364103621 date "2010-01-01" @default.
- W2364103621 modified "2023-09-24" @default.
- W2364103621 title "Image cytophotometric analysis of DNA stemline ploidy heterogeneity of hepatocellular carcinoma in tissue sections" @default.
- W2364103621 hasPublicationYear "2010" @default.
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