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- W2364110473 abstract "Objective To examine whether the allicin has beneficial effects in the treatment of pulmonary hypertension and ultrastructural changes induced by monocrotaline (MCT). Methods One hundred and ninety eight male Wistar rats weighing from 180 g to 200 g were randomly divided into three groups: ① Pulmonary hypertension (PH) group ( n =66) treated with MCT(80 mg/kg, ih); ② Allicin group ( n =66)treated with MCT+Allicin 〔15 mg/(kg·d)〕;③ Control group ( n =66), treated with NS. Results The results showed that:① In MCT group, the pulmonary arterial pressure increased to maximum level at d 28 after injection of MCT attaining to (5.83±0.22) kPa as compared to the control of (2.91±0.04) kPa ( P 0.01); ② In allicin group, the pulmonary arterial pressure decreased to (4.51±0.22) kPa and the total pulmonary resistance (TPR) decreased from (1 483 05±157 97)U (MCT group) to (637.15±19.26)U ( P 0.01);③ The responsiveness of pulmonary artery to norepinephrine(10 4 mol/L) was significantly reduced in allicin group; ④ The blood gas (PO 2, PCO 2 and pH) changes induced by MCT was also remarkably attenuated by administration of allicin ( P 0.01); ⑤ All of the ultrastructural changes (including the thickening of pulmonary media layer, musculinization of pulmonary artery, decrease in Ⅰ type collagenous fibers, pathologic changes of endothelial cells and platelet aggregation, etc.) were significantly alleviated by administration of allicin. The mechanisms responsible for the actions of allicin were discussed. Conclusion It is indicated that allicin has definite beneficial effects in the treatment of pulmonary hypertension." @default.
- W2364110473 created "2016-06-24" @default.
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- W2364110473 date "2001-01-01" @default.
- W2364110473 modified "2023-09-25" @default.
- W2364110473 title "Studies on the role of allicin in inhibiting pulmonary remodeling and in the development of pulmonary artery" @default.
- W2364110473 hasPublicationYear "2001" @default.
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