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- W2364113818 abstract "Objective To investigate the effects of conventional immunosuppressants on chime- rism and tolerance induced by allogeneic bone marrow transplantation in combination with CTLA4- FasL gene transfer mediated by adenovirus.Methods C57BL/6(H-2~b,B6) mice received BALB/c(H- 2~d) mice skin transplantation,followed by both adenovirus vector encoding CTLA4-FasL gene and bone marrow cells (BMC) of BALB/c mice injected via tail vein.Cyclosporine A (CsA) or mycopheno- late mofetil (MMF) or both was administered daily from day 0 through 28 after donor skin transplan- tation.Then,the survival of skin grafts was observed,the level of Vβ11~+ T cells and donor chimerism were detected by flow cytometry,and tolerance to donor antigen was evaluated through one-way MLR. Results In non-cytoreductive model using BMT and CTLA4-FasL gene transfer,short-course immu- nosuppression facilitated early engraftment of donor bone marrow,while the mixed chimerism in peripheral blood of B6 recipients treated with CsA or both CsA and MMF were reduced to very low level on day 140 after skin transplantation.As compared with 136 recipients treated with MMF or no immunosuppressants,the mean survival time (MST) of skin allografts in those mice treated with CsA or both CsA and MMF was significantly reduced,and the levels of Vβ11~+ T cell were significantly in- creased.Furthermore,B6 recipients treated with CsA or both CsA and MMF showed no tolerance to donor antigen.Conclusion Immunosupressive regime containing CsA could abrogate long-lasting mixed chimerism induction and tolerance development in non-cytoreductive model using BMT and CTLA4-FasL gene transfer,owing to negative effect of CsA on peripheral deletion of donor-specific T cells." @default.
- W2364113818 created "2016-06-24" @default.
- W2364113818 creator A5091339472 @default.
- W2364113818 date "2006-01-01" @default.
- W2364113818 modified "2023-09-22" @default.
- W2364113818 title "Effects of short-course immunosuppression on chimerism and tolerance induced by BMT without cytoreductive conditioning" @default.
- W2364113818 hasPublicationYear "2006" @default.
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