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- W2364117486 abstract "Objective:To study the antioxidative effect of isoliensinine in D-Galactose-induced aged mice.Methods:The fifty mouses were randomly divided into five groups involved in black group,model group,low-dose isoliensinine group(10 mg/kg),high-dose isoliensinine group(20 mg/kg) and the group treated with Vitamin C.The body weight and the liver index were determined and the activities of super-oxide dismutase(SOD),glutathione peroxidase(GSH-Px) and the contents of malonic dialdehyde(MDA) in serum and liver tissue were assayed respectively.Results:Compared with black group,for aging model mice,the body weight and the liver index declined,the data were 32.87 g and 3.87 mg/g,the activities of SOD and GSH-Px in surum and liver tissue also declined,the data were 247,408 U/ml and 358,319 U/mgpro,and the contents of MDA raised,the data were 20.62 nmol/ml and 13.01 nmol/mgpro(P0.01).In comparison with the model group,the loss of body weight and the liver index were markedly counteracted,the activities of SOD and GSH-Px in surum and liver tissue of isoliensinine group(20 mg/kg) were all increased and the contents of MDA got high reduction(P0.01),the data were 36.29 g,4.53 mg/g,305,459 U/ml,438,355 U/mgpro and 16.47 nmol/ml respectively.The activities of GSH-Px in liver tissue was 333 U/mgpro and had no marked effect compared with model group.Conclusion:Isoliensinine can significantly increase the antioxidative effect of D-Galactose-induced aged mice." @default.
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- W2364117486 date "2011-01-01" @default.
- W2364117486 modified "2023-09-24" @default.
- W2364117486 title "Study on antioxidation of Isoliensinine in D-Galactose-induced aged mice" @default.
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