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- W2364121175 abstract "Objective:To observe the low-dose(40 μg/ml) paclitaxel(PTX) combined with recombinant human endostatin(rh-ES) in inhibiting the growth of human breast cancer MCF-7 cell line and suppressing the gene expression of vascular endothelial growth factor(VEGF).Methods:The experiment had four groups:control group(group A),group PTX(group B),group rh-ES(group C) and group PTX + rh-ES(group D).It enumerated the surviving MCF-7 cells after 24 h,which were treated with the four methods.Inhibitory rate of cells of the four groups was calculated.The VEGF protein and mRNA expressions were detected by immunocytochemistry and RT-PCR.Results:The inhibitory rate of group D was higher than that of group C(P=0.002),but there was no statistic significance of inhibitory rate between group D and group B(P=0.57).When VEGF protein and mRNA expressions were compared between each group,those in group D were significantly lower than in the other three groups(P0.05).The increased inhibitory rate of MCF-7 cells and the decreased expression of VEGF were in linear correlation(r=0.564,P0.001).Conclusion:Low-dose PTX combined with rh-ES can obviously inhibit the growth of MCF-7 cell line and suppress gene expression of VEGF.Our results demonstrate the combined use of low-dose PTX and rh-ES has synergistic effects in inhibiting tumor growth and angiogenesis." @default.
- W2364121175 created "2016-06-24" @default.
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- W2364121175 date "2011-01-01" @default.
- W2364121175 modified "2023-09-28" @default.
- W2364121175 title "Inhibitory effect of low-dose paclitaxel combined with recombinant human endostatin on breast cancer MCF-7 cell line" @default.
- W2364121175 hasPublicationYear "2011" @default.
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