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- W2364127084 abstract "Objective To investigate metabolite concentrations abnormalities in patients of disorders of cerebral cortical development(DCDs)accompanied with epilepsy with 1H-MRS.Methods Twenty patients of DCDs accompanied with epilepsy and twenty-five healthy controls were collected.All of them underwent 1H-MRS scanning.The ratio of N-acetylaspartate/creatine(NAA/Cr)in 20 patients with DCDs were measured in the lesion areas,the adjacent areas and the regions remote to the visible lesions,and were compared with those of similar brain regions of 25 normal control subjects.Results The ratios of NAA/Cr significantly decreased in the lesions and adjacent areas of focal cortical dysplasia compared with the controls' regions(P0.01),but no significant difference was found in lesions or adjacent areas of heterotopia compared with that of controls' regions(P0.05).The ratios of NAA/Cr decreased in the lesions of schizencephaly compared with the controls' regions(P0.05),whereas no significant defference of metabolite ratios was found between the adjacent areas and the normal regions of the controls(P0.05).There was no significant difference of the metabolite ratios among the regions remote to the visible lesions of three kinds of DCDs and those of the controls' regions(P0.05).Conclusion The metabolic properties of three kinds of DCDs might be distinguished with multivoxel 2D1H-MRS,which provides a new approach for DCDs at molecular metabolite level." @default.
- W2364127084 created "2016-06-24" @default.
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- W2364127084 date "2009-01-01" @default.
- W2364127084 modified "2023-09-22" @default.
- W2364127084 title "Magnetic resonance spectroscopy of patients with disorders of cerebral cortical development" @default.
- W2364127084 hasPublicationYear "2009" @default.
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