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- W2364128227 abstract "Objective To investigate the effect of AMPK and HO-1 activation on hypertrophic cardiac myocyte,and the effect of HO-1 in the mechanism of AMPK inhibition of cardiomyocyte hypertrophy.Methods Cultured rat neonatal cardiacmyocytes were incubated with Ang Ⅱ to induce cardiac hypertrophy.Cardiac myocyte surface area and [3H]leucine incorporation was measured to determine the effect of AMPK and HO-1 on cardiac hypertrophy.The effect of 5-aminoimidazole-4-carboxamide ribonucleoside(AICAR) on adenosine monophosphate activated protein kinase(AMPK) phosphorylation and HO-1 activaton were detected by Western blot.Results Compared with control group,activated AMPK significantly enhanced the transcriptive activity of AMPK,and increased HO-1 protein expression in cardiac myocyte.The increasement of cell surface area by Ang Ⅱ was significantly inhibited after treatment of AICAR.However,this inhibitory effect was attenuated by HO-1 inhibitor.Conclusion AMPK can attenuate the cardiac hypertrophy induced by Ang Ⅱ,AMPK can upregulate the HO-1 in cardiac hypertrophy induced by AngII.HO-1 play a significant role in the effect of the AMPK on inhibiting cardiac hypertrophy." @default.
- W2364128227 created "2016-06-24" @default.
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- W2364128227 date "2010-01-01" @default.
- W2364128227 modified "2023-09-27" @default.
- W2364128227 title "AMPK Inhibits Cardiomyocyte Hypertrophy Via Induction of Heme Oxygenase-1" @default.
- W2364128227 hasPublicationYear "2010" @default.
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