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- W2364128274 abstract "AIM: To investigate the association of homocysteine(Hcy) levels in plasma and tear with ocular surface damage in the patients with type 2 diabetes.METHODS: The plasma and tear levels of Hcy in 40 patients with type 2 diabetes and 40 age-and sex-matched normal controls were measured by high-performance liquid chromatography with fluorescence detection(HPLC-FD).These 40 diabetic patients(80 eyes) and 40 normal controls(80 eyes) received fundus fluorescence angiography,determination of corneal sensitivity,basic tear secretion assay,tear film breakup time test,corneal fluorescein staining and conjunctival rose bengal staining.All the results were quantified and analyzed by SPSS 13.0 statistical analysis software.RESULTS: It was the first time that Hcy had been detected in tear.The plasma and tear levels of Hcy in diabetic patients were significantly higher than those in controls(P0.01).The concentration of Hcy increased both in plasma and tear with the severity of diabetic retinopathy(P0.01).A statistically significant correlation between tear Hcy concentration and diabetic ocular surface diseases was observed. CONCLUSION: The raise of Hcy level in tear and plasma of the diabetic patients may be involved in the occurrence of diabetic ocular surface damage." @default.
- W2364128274 created "2016-06-24" @default.
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- W2364128274 date "2011-01-01" @default.
- W2364128274 modified "2023-09-23" @default.
- W2364128274 title "Association of ocular surface damage with homocysteine levels in plasma and tear in patients with type 2 diabetes mellitus" @default.
- W2364128274 hasPublicationYear "2011" @default.
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