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- W2364129170 abstract "Purpose To screen the optimal conditions of cross-linking reaction,to prepare injectable cross-linked sodium hyaluronate gel(HA-gel)with hight resistance to hyaluronidase(HAas)degradation,and to research on the determination of resistance to HAas in vitro.Methods The HA-gel was prepared using 1,4-butanediol diglycidyl ether(BDDE),and its resistance to HAas in vitro was determined.The optimal reaction conditions were define by orthogonal test of six factors.Results HAas had no interference in determination of resistance to HAas in vitro.A linear relationship between the concentration of HAas(100～500 U/mL)and the absorbance of colored product was shown(r=0.998 8).The result of orthogonal test by range analysis and variance analysis showed that the initial concentration of HA and the ratio of HA to cross-linking agent were significant factors.The optimal conditions of the parameters were 1% NaOH,50℃,4 h,10% BDDE/HA and HA with average relative molecular mass of 1.2×106 and concentration of 15%.Conclusion The HA-gel with excellent resistance to enzymatic degradation can be prepared under optimal reaction conditions,which establishes foundation to develop injectable cosmetic products." @default.
- W2364129170 created "2016-06-24" @default.
- W2364129170 creator A5070806328 @default.
- W2364129170 date "2008-01-01" @default.
- W2364129170 modified "2023-09-22" @default.
- W2364129170 title "Preparation of cross-linked sodium hyaluronate gel for injection and research on its resistance to enzymatic degradation in vitro" @default.
- W2364129170 hasPublicationYear "2008" @default.
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