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- W2364145774 abstract "Objective To prepare chitosan microparticles based on influenza vaccine liposome, and determine the preparation technology of chitosan liposome vaccine.Methods We prepared chitosan microparticles with different N/P ratio based on influenza vaccine liposomes which were produced by film dispersion method. Then we observed the morphology and determined the average particle size and particle size distribution,entrapment efficiency and the binding rate. By comparing the encapsulation rate and binding rate of different N/P ratio chitosan nanoparticles, the preparation technology of chitosan liposome vaccine was preliminary determined. Results Influenza vaccine liposomes coated with chitosan were round or oval with uniformed particle size distribution. The average particle size increased from 2.14 μ m to 4.05 μ m, and the average encapsulation rate increased from 80.41% to 84.37% after coated liposomes with chitosan. By comparing 6 N/P ratio, the ration of 5:1 was the best ratio in terms of binding rate which was 19.40%.Conclusions Chitosan coated liposomes is circular with increased particle size and encapsulation rate. 5:1 ratio of N/P is the optimum proportion concerning the incubation of chitosan and liposome." @default.
- W2364145774 created "2016-06-24" @default.
- W2364145774 creator A5079638376 @default.
- W2364145774 date "2014-01-01" @default.
- W2364145774 modified "2023-09-23" @default.
- W2364145774 title "Study on Preparation of Chitosan Coated Influenza Vaccine Liposome" @default.
- W2364145774 hasPublicationYear "2014" @default.
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