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- W2364146245 abstract "Objective To investigate the effect of IL-18 on apoptotic induction in ovarian epithelial carcinoma.Methods Twenty-four nude mice with ovarian papillary serous cystadenocarcinoma HO 8910 cell lines were randomly divided into 4 groups,and each group received intraperitoneal injection of IL-18 at various doses(0,2.5,5 and 10 mg/L) for 7 days.The morphology and apoptosis of specimen were observed by light microscopy,transmission electron microscopy(TEM) and TUNEL,respectively.Results There existed apoptotic cells in treatment group I and II.Necrosis occurred in treatment group III.Apoptotic index was significantly higher in treatment group than that in control group(P0.01),especially in treatment group II,but there was no statistical difference between treatment group I and III(P0.05).Conclusion IL-18 induced apoptosis in ovarian epithelial carcinoma may be involved in its antineoplasmic mechanism." @default.
- W2364146245 created "2016-06-24" @default.
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- W2364146245 date "2008-01-01" @default.
- W2364146245 modified "2023-09-23" @default.
- W2364146245 title "IL-18 induced the apoptosis in nude mice bearing ovarian papillary serous cystadenocarcinoma" @default.
- W2364146245 hasPublicationYear "2008" @default.
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