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- W2364149849 abstract "Objective To explore the application of procalcitonin( PCT) and clinical pulmonary infection score( CPIS) in the diagnosis of patients with ventilator-associated pneumonia( VAP).Methods A total of 59 patients required invasive mechanical ventilation( IMV) in intensive care union( ICU) were selected,in which 35 cases with VAP within 7 days were designed as VAP group,while another 24 cases without VAP were designed as non-VAP group. Relevant inflammatory markers such as serum PCT and C-reactive protein( CRP) as well as blood routine were detected before IMV and CPIS scoring was conducted. The above indexes were detected immediately after VAP in VAP group and 7 days after IMV in non-VAP group. Results After IMV,levels of PCT and CRP increased evidently in VAP group( P 0. 01),but there were no significant differences in PCT,CRP and white blood cell count( WBC) in non- VAP group( P 0. 05), and the levels of PCT and VAP were significantly higher in VAP group than in non- VAP group( P 0. 01). The area under ROC curve of VAP diagnosed by PCT was 0. 876,and the diagnostic value was high. With PCT≥0. 4 μg / L as the positive threshold value,the diagnostic sensitivity and specificity were 91. 4%( 32 /35) and 70. 8%( 17 /24) respectively,and further diagnosis combing with CPIS showed that the specificity was up to 100%( 24 /24). Additionally, PCT was associated with CPIS( P = 0. 0 0 2),but there was no obvious correlation between CRP and CPIS( P =0. 286). Conclusion PCT has high sensitivity and specificity in the diagnosis of VAP,and combining with CPIS score can increase the diagnostic specificity." @default.
- W2364149849 created "2016-06-24" @default.
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- W2364149849 date "2015-01-01" @default.
- W2364149849 modified "2023-09-23" @default.
- W2364149849 title "Application of PCT combined with CPIS in diagnosis of patients with VAP" @default.
- W2364149849 hasPublicationYear "2015" @default.
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