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- W2364151343 abstract "Objective To observe the effect of Shengmai Selenium on myocardial ischemic injury rats induced by isoproterenol(ISO).Methods Wistar rats were randomly divided into control group,model group,Shengmai group and high-,medium-,low-dose of Shengmai Selenium group.Acute myocardial ischemic injury model was made by intraperitoneal injection of ISO.Shengmai group was given Shengnai Injection 10 mg/(kg.d) by gavage,control group and model group were given equal volume NS,and high-,medium-,low-dose of Shengmai Selenium group was given mixture of Shengmai injection and selenium-enriched malt extraction 20,10,5 mg/(kg.d).Myocardial tissue change in the structure was observed.SOD activity and MDA content were determined and the expression of apoptotic protein Bax/Bcl-2 was observed by immunohistochemistry method.Results Shengmai group and Shengmai Selenium group significantly reduced myocardial infarct size,and elevated serum SOD activity(P 0.05),decreased MDA content(P 0.05).Immunohistochemistry showed that positive expression of Bcl-2 protein in Shengmai Selenium group increased significantly(P 0.01).High-,medium-dose of Shengmai Selenium group and Shengmai group significantly inhibited the expression of Bax protein(P 0.01).Conclusion Shengmai Selenium has myocardial protective effect on acute myocardial ischemic injury rat model.Its mechanism may be related with its antioxidant effect and against myocardial cell apoptosis." @default.
- W2364151343 created "2016-06-24" @default.
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- W2364151343 date "2013-01-01" @default.
- W2364151343 modified "2023-09-28" @default.
- W2364151343 title "Effect of Shengmai Selenium on Acute Myocardial Ischemic Injury Rats" @default.
- W2364151343 hasPublicationYear "2013" @default.
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