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- W2364152816 abstract "Aim: To investigate the protective effect of heme oxygenase-1(HO-1) induced by SnCl_2 on renal ischemia and reperfusion injury in rats. Methods: A total of 48 Wistar rats were allocated into sham-operation, model control group and experimental group randomly. In the experimental group, SnCl_2 was administered subcutaneously at 24 h prior to the renal artery clamp for 45 min in order to prepare the ischemia model. After 24 h reperfusion, the kidney was removed to detect the levels of HO-1 using immunohistochemistry and double antibody capture ELISA, respectively, SOD activity and MDA content in the renal tissue were examined.The renal function was also assessed by determining the levels of blood urea nitrogen(BUN) and serum creatinine (Cr).Results: HO-1 levels increased in sequence of sham-operation group,control group,and experimental group(P0.05).There were significant differences in BUN,Cr, SOD activity and MDA before and after reperfusionin in control group(P0.05 ),but not in sham-operation and experimental group(P0.05). Conclusion: Pretreated renal tissue with SnCl_2 can induce HO-1 that can reduce ischemia reperfusion injury through the way of scavenging the toxic free radicals." @default.
- W2364152816 created "2016-06-24" @default.
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- W2364152816 date "2005-01-01" @default.
- W2364152816 modified "2023-09-27" @default.
- W2364152816 title "Protective effect of induced heme oxygenase-1 by SnCl_2 on renal ischemia and reperfusion injury in rats" @default.
- W2364152816 hasPublicationYear "2005" @default.
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