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- W2364153516 abstract "Purpose:To study the effects of overexpression of p21 WAF1/CIP1(p21 gene) on the malignant phenotype and apoptosis of human gastric cancer cell, to further understand the mechanism of action of the tumor-suppressor gene p21. Methods:An adenoviral expression vector with full length cDNA of p21 gene insert was constructed(Ad-p21) and transfevted into SGC-7901 cells with p53 mutation. The effect of exogenous p21 gene on the growth of SGC-7901 cells was examined in vitro and in vivo.Results:Expression of p21 gene in SGC-7901 cells was confirmed by FCM. The in vitro growth of the Ad-p21 transfected SGC-7901 cells was significantly inhibited (inhibition rate: 82%) as compared to mock (Ad-lacZ) transfected SGC-7901 cells. Colony-forming activity in vitro of Ad-p21 transfected SGC-7901 cells was completely inhibited. Morphologically, the Ad-p21 transfected cells appeared apoptotic which was confirmed by the appearance of pre-G 1 on flow cytometry and DNA fragmentation. The growth of SGC-7901 xenografts in nude mice was retarded by intratumoral injection of Ad-p21. Conclusions:p21 gene participates in the induction of cell apoptosis. Its use for gene therapy of cancer, especially when combined with other apoptosis-inducing agents is promising." @default.
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- W2364153516 date "2002-01-01" @default.
- W2364153516 modified "2023-09-26" @default.
- W2364153516 title "Apoptosis of human gastric cancer cell line SGC-7901 by p21 gene transduction" @default.
- W2364153516 hasPublicationYear "2002" @default.
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