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- W2364153986 abstract "Objective:To determine the risk factors for failture of an ectopic pregnancy(EP)with single-dose methotrexate.Methods:The clinical data of patients after a single-dose methotrexate for EP in Renmin Hospital of Wuhan University from July 2006 to July 2011 was reviewed retrospectively.Results:Two hundred and sixty-nine cases of EP were reviewed.The cases were divided into twogroups.One group(19.3%) were cases with ruptured EP and another group were 144(80.7%) cases with unruptured EP.failure group and successful group according to the outcome.Fifty-two of them The mean level of pretreatment β-hCG,ratio of previous EP,mean gestation(in weeks),and size of the gestational mass were significantly higher in patients with ruptured EP compared with patients with unruptured EP(P0.05).Logistic regression analysis revealed that 2 000～5 000 IU/L of pre-hCG level and≥5 000 IU/L of pre-hCG levels and also 6～8 weeks of amenorrhoea and 8 weeks of amenorrhoea and size of the gestational mass≥4 cm were the significantly risk factors for tubal rupture(P0.05).No significantly associations existed regarding age,previous normal deliveries,previous induced abortion,prior pelvic surgery and use of an intra-uterine contraceptive device(IUD).The receiver operating characteristic(ROC) curve cutoff value in the success group indicated an initialβ-hCG level of 1 871.5IU/L.At the value of 1 871.5 IU/L,sensitivity and specificity in the success group reached 82.7% and 70%.The area under the curve reached 0.8(P0.05).Conclusions:Higher initial β-hCG level,higher gestational age and size of the gestational mass seem to be significant risk factors for failure of single-dose methotrexate therapy,Methotrexate should be used with caution in patients with EP." @default.
- W2364153986 created "2016-06-24" @default.
- W2364153986 creator A5010167248 @default.
- W2364153986 date "2012-01-01" @default.
- W2364153986 modified "2023-09-23" @default.
- W2364153986 title "Therapeutic Effect of Single-dose Methotrexate for Ectopic Pregnancy" @default.
- W2364153986 hasPublicationYear "2012" @default.
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