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- W2364156345 abstract "[Objective] To offer scientific basis for health education and decision of prevention,by exploring smoking associated with liver cancer risk through meta-analysis.[Methods] Taking into account the possibility of heterogeneity test,random effect Meta-analysis model was used to calculate the combined odds Ratio(OR) of association strength between smoking and liver cancer,meanwhile publication bias was also evaluated.Generalized least squares(GLS) for trend estimation of summarized dose-response relationship between the amount of smoking and risk of liver cancer was carried out.[Results] A total number of 10 228 cases and 22 312 controls from 50 studies were included.There was heterogeneity in these studies after test of heterogeneity(q = 267.75,P﹤0.000 01).Compared to those who never smoke,the combined OR of smoking was 1.43(95%CI:1.25-1.63).The combined OR values of category by region(Asia,central and north America,Europe) were 1.46(1.24-1.72),1.65(1.29-2.10) and 1.14(0.83-1.57),respectively,by country(domestic,foreign) were 1.32(1.07-1.63) and 1.51(1.28-1.78),respectively,by the control group(healthy people,non-HCC patients) were 1.41(1.21-1.64) and 1.44(1.18-1.75),respectively,by types of research design(case-control,nested case-control) were 1.47(1.29-1.68) and 1.00(0.54-1.82),respectively,which were near to the combined OR of smoking.With increasing the amount of smoking,the risk of liver cancer was increasing,there was a significant dose-response relationship between the amount of smoking and risk of liver cancer(Z = 4.76,P﹤0.0001).[Conclusion] Smoking is a weak risk factor for liver cancer." @default.
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- W2364156345 date "2010-01-01" @default.
- W2364156345 modified "2023-09-23" @default.
- W2364156345 title "META-ANALYSIS OF THE ASSOCIATION BETWEEN SMOKING AND LIVER CANCER" @default.
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