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- W2364156893 abstract "Objective To explore the toxicity effects of realgar on male rat sperm.Methods Parts of male rats in reproductive toxicity test(stage Ⅰ,fertility and early embryonic development) were utilized to analyse the sperm quality effected by oral administration of realgar.Fifty male rats were randomly divided into the negative control goup,the positive control Tripterysium Glycosides group(10 mg/kg) and realgar groups(50,125,250 mg/kg respectively).The rats were orally administered with corresponding drugs daily for 6 weeks.All rats were sacrificed on the 42nd day and one epididymide from each rat was taken to evaluate sperm motility by CASA.Testises and epididymides were collected to observe histopathological changes by HE staining.Results Compared with negative control group,the sperm motility,effective spermcount,sperm dentisty and motility parameter(except BCF) in positive control Tripterysium Glycosides group reduced significantly(P0.01).While in reaglar groups,no obviously changes were seen(P0.05),and there was no statistically significant difference among different dose of reaglar groups(P0.05).Histopathological observation showed that,in the positive control Tripterysium Glycosides group,testis seminiferous tubule atrophied,spermatogenic cells decreased,and there were a large number of degradated spermatogenic cells and cell debris in epididymal lumen,sperm cells reduced,stereocilia became short.The high-dose group of realgar had no significant histological pathology changes in testis and epididymides.Conclusion Realgar has no significant toxicity on male rats sperm." @default.
- W2364156893 created "2016-06-24" @default.
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- W2364156893 date "2012-01-01" @default.
- W2364156893 modified "2023-09-28" @default.
- W2364156893 title "Effect on Male Rat Sperm Quality by Oral Administration of Realgar" @default.
- W2364156893 hasPublicationYear "2012" @default.
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